Dengvaxia won’t bring dengue cases down – DOH

Maris Federez   •   August 8, 2019   •   360

The controversial dengue vaccine, Dengvaxia

The Department of Health (DOH) on Thursday maintained that Dengavaxia is not the answer to the problem of the high incidence of dengue in the country.

DOH spokesperson and Officer in Charge of the Food and Drug Administration, Usec. Eric Domingo explained that dengue is not like any other disease where vaccination is the only solution.

He stressed that Dengvaxia is still not a registered drug in the country and its efficacy is not yet fully proven.

“This vaccine is not for an outbreak response. It’s designed for future use sa mga taong nagka- dengue na dati [for people who have had dengue before],” Domingo said.

A World Health Organization (WHO) report showed that “Dengvaxia was first licensed in Mexico in December 2015 for use in individuals 9-45 years of age living in endemic areas, and is now licensed in 20 countries.”

It was then used in 11 countries in 2016, including the Philippines.

But it was only in September 2018 that the WHO recommended that Dengvaxia be only administered to children who were previously infected with dengue, adding that it is dangerous for those who have not yet gotten the disease.

This caused among the public, as well as, experts as the Philippines is the only country who had used Dengvaxia vaccination on a wider scope, with more than 800,000 children inoculated.

The DOH maintained that there is still no concrete study to date that claimed that children who are vaccinated with Dengvaxia will never be infected with dengue.

“It’s very difficult because you’re tested and then you’re positive but you’re actually false positive. Then if you give the Dengvaxia, who knows that the severe dengue reaction will not occur in a particular individual. So, there’s a risk, in other words,” DOH Secretary Francisco Duque III said.  (with details from Aiko Miguel) /mbmf

Plastic particles in drinking water present ‘low’ risk – WHO

Robie de Guzman   •   August 23, 2019

Microplastics contained in drinking water pose a “low” risk to human health at current levels, but more research is needed to reassure consumers, the World Health Organization (WHO) said on Thursday (August 22).

Studies over the past year on plastic particles detected in tap and bottled water have sparked public concerns, but the limited data appears reassuring the U.N. agency said in its first report on potential health risks associated with ingestion.

Microplastics enter drinking water sources mainly through run-off and wastewater effluent, the WHO said. Evidence shows that microplastics found in some bottled water seem to be at least partly due to the bottling process and/or packaging such as plastic caps, it said.

It added however that the current and available studies on the toxicity of plastic parts are limited, and also have not used standardized methods enabling scientists to have reproducible and comparable metrics, and that more studies are needed to be more conclusive on certain of the issues.

Microplastics pose three threats, a physical one, a chemical and the third is about bacterial colonization.

The majority of plastic particles in water are larger than 150 micrometers in diameter and are excreted from the body, while the vast majority of smaller ones are likely to be excreted too, there still remains concern. WHO technical experts reported that more research needs to be conducted to know more about what is being absorbed, the distribution and their impacts.

The chemical hazard, experts have looked at the concentrations found in marine microplastics and chose a worst-case scenario saying we would ingest the highest possible concentrations. According to WHO, whatever the chemical, the exposure level was a lot safer than any threshold of risks.

Bacterial colonization, health experts say there are so many particles in the environment bacteria might adhere to, that microplastics would make a negligible contribution to any microbioflora that would be released and pose a risk.

For this report, however, despite the flaws, they say they worked with worst-case scenarios and are confident that the risk would remain low should some data change.

The WHO recommended for consumers to keep on consuming tap or bottled water, provided it is correctly treated, and didn’t recommend for any regulations to be put in place. It also called for more studies, investigating the potential cumulative effects of the ingestion of microplastics present in food, air, water.

The biggest overall health threat in water is from microbial pathogens —including from human and livestock waste entering water sources — that cause deadly diarrhoeal disease, especially in poor countries lacking water treatment systems, the WHO said.

Some 2 billion people drink water contaminated with faeces, causing nearly 1 million deaths annually, Gordon said, adding: “That has got to be the focus of regulators around the world.”

Plastic pollution is so widespread in the environment that you may be ingesting five grams a week, the equivalent of eating a credit card, a study commissioned by the environmental charity WWF International said in June.

That study said the largest source of plastic ingestion was drinking water, but another major source was shellfish. (Reuters)

(Production: Marina Depretis, Emilie Delwarde)

DOH agrees with FDA decision to ban Dengvaxia in Phl

Maris Federez   •   August 22, 2019

A Filipino nurse prepares to administer an anti-dengue vaccine during a nationwide vaccination at a school in the flood-prone city of Marikina, east of Manila, Philippines, 04 April 2016. (Photoville International / FILE)

The Department of Health (DOH) has rejected the request of Sanofi Pasteur to overturn the decision of the Food and Drug Administration (FDA) to ban the use of Dengvaxia vaccine in the Philippines.

With this, the DOH approved the ruling of the FDA to permanently revoke the certificate of product registration of Dengvaxia for Sanofi’s failure to submit the necessary post-approval requirements.

“The decision concerns Sanofi’s complete disregard of FDA regulations, which were precisely put in place by law to ensure safety,” DOH Secretary Francisco Duque III said in a statement.

Although Sanofi was able to submit the first two versions of its risk management plans (RMP), the pharmaceutical company failed to submit the third and final version of the plan.

The DOH said, however, that Sanofi may apply for a new certificate of product registration (CPR) for Dengvaxia but this must be in accordance with the FDA regulations.

“Given that Dengvaxia is an innovative drug, the importance of complying with these post-marketing commitments is critical to public safety,” the statement added.

Meanwhile, the department has assured that it continues to address the increasing cases of dengue in the country. /mbmf

DOH Region 3: Over 100 Chinese workers, now dengue free

Aileen Cerrudo   •   August 21, 2019

The Department of Health (DOH) Region 3 has reported that the over 100 Chinese workers who contracted dengue in Morong, Bataan are now free of the disease.

The Chief of the Regional Epidemiology Surveillance Unit of DOH Region 3 Dr. Jessie Fantone said 69 of the Chinese workers have contracted dengue last March. The remaining 35 were reported to have contracted the diseases this August.

“All of them got well and wala namang namatay. Kaya lang noong pinuntahan namin iyong plant nila marami silang areas na stagnant water na breeding sites (There were no fatalities, but when we visited their plant, there was a lot of stagnant water which can be become breeding sites),” he said.

Meanwhile, cleaning operations continue at the barangay where the coal plant is located.—AAC (with reports from Aiko Miguel)

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